Affinity for a Malignant Tumor and Organs at the Elements in Group VIII of the Periodic Table

ANDO Atsushi, HISADA Kinichi, ANDO Itsuko

doi:10.3769/radioisotopes.24.12_878

In order to investigate the tumor affinity radioisotopes, iron (Fe-59), cobalt (Co-58), ruthenium (Ru-103), Palladium (Pd-103), Osmium (Os-185+191) and iridium (Ir-192) -the elements of group VIII in the periodic table-were examined, using the rats which were subcutaneousl y transplanted with Yoshida sarcoma. Six preparations, ⁵⁹Fe-chloride, ⁵⁸Co-chloride, ¹⁰³Ru-chloride, ¹⁰³Pd-chloride, ^185+191Os-hexachlorosmic acid and ¹⁰³Ir-hexachloriridic acid were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations but ⁵⁹Fe-chloride, 30 minutes, 3 hours, 24 hours and 48 hours in ⁵⁹Fe-chloride. The radioactivities of the tumor, blood, muscle, liver, kidney and spleen were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor were calculated in percent of administered dose per g-tissue weight) .<BR>^185+191Os-hexachlorosmic acid had considerably strong affinity for the malignant tumor. ⁵⁹Fe-chloride, ⁵⁸Co-chloride, ¹⁰³Ru-chloride, ¹⁰³Pd-chloride and ¹⁹²Ir-hexachloriridic acid did not have any affinity for malignant tumor. But ⁵⁹Fe-chloride had very strong affinity for blood-corpuscles.<BR>103Pd-chloride had fairly strong affinity for the kidney and liver, ⁵⁸Co-chloride had fairly affinity for the liver, ¹⁰³Ru-chloride, ^185+191Os-hexachlorosmic acid and ¹⁹²Ir-hexa-chloriridic acid had fairly strong affinity for the kidney.

Affinity for a Malignant Tumor and Organs at the Elements in Group VIII of the Periodic Table

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