Distribution of Heparin-<SUP>67</SUP>Gai in Tumori-Bearing Rats

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  • ヘパリン-<SUP>67</SUP>Gaの担がんラットにおける体内分布
  • ヘパリン 67Ga ノ カツガン ラット ニ オケル タイナイ ブンプ

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Abstract

Heparin is a kind of acidic mucopolysaccharide. Heparin-67Ga complex was prepared to investigate distribution in tumor-bearing rats. This compound was intravenously injected to the rats subcutaneously transplanted Yoshida sarcoma. These rats were sacrificed at 10 minutes, 30 minutes, 1 hour and 3 hours after injection. The radioactivities of the tumor, blood, muscle, liver, kidney, spleen and urine were measured by well-type scintillation counter. The retention values in these organs and the excretion rates in the urine were calculated. Excretion rates (%/dose) of heparin-67Ga in 10 min., 30 min., 1 hours and 3 hours were 38.2%, 67.5%, 79.5% and 78.0%, respectively. From these facts, it was thought that heparin-67Ga complex had not suitable property for tumor scanning, but this compound might be suitable agent for renal function test.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 25 (6), 329-332, 1976

    Japan Radioisotope Association

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