Relation between Location of Elements in Periodic Table and Affinity for the Malignant Tumor
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- ANDO Atsushi
- Schools of Paramedicine, Kanazawa University
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- HISADA Kinichi
- Medicine, Kanazawa University
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- ANDO Itsuko
- Medicine, Kanazawa University
Bibliographic Information
- Other Title
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- 元素の周期律表での位置と悪性腫瘍親和性との関連に関する考察
- ゲンソ ノ シュウキリツヒョウ デ ノ イチ ト アクセイ シュヨウ シンワセ
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Description
Affinity of many inorganic compounds for the malignant tumor was examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. And the relations between the uptake rate into the malignant tumor and in vitro binding power to the protein were investigated in these compounds.<BR>In these experiments, the bipositive ions and anions had not affinity for the tumor tissue with a few exceptions. On the other hand, Hg, Au and Bi, which have strong binding power to the protein, showed high uptake rate into the malignant tumor. As Hg++, Au+ and Bi+++ are soft acids according to classification of Lewis acids, it was thought that these elements would bind strongly to soft base (R-SH, R-S-) present in the tumor tissue.<BR>In many hard acids (according to classification of Lewis acids), the uptake rate into the tumor was shown as a function of ionic potentials (valency/ionic radii) of the metal ions.<BR>It is presumed that the chemical bond of these hard acids in the tumor tissue is ionic bond to hard base (R-COO-, R-PO32-, R-SO3-, R-NH2) .
Journal
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- RADIOISOTOPES
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RADIOISOTOPES 26 (10), 689-695, 1977
Japan Radioisotope Association
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Details 詳細情報について
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- CRID
- 1390001204157697536
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- NII Article ID
- 130004126903
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- NII Book ID
- AN00351589
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- ISSN
- 18844111
- 00338303
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- NDL BIB ID
- 1847042
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- PubMed
- 579459
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed