Application of Low Background Liquid Scintillation Counting Method to Pharmacy:I. Measurement of Ultra-low Level 14C Activity in Urine

BABA Shigeo, HORIE Masanobu, YANAGI Mashiho, KATO Yuka, YOSHIMURA Tomoyuki

doi:10.3769/radioisotopes.58.169

Bibliographic Information

Other Title

低バックグラウンド液体シンチレーション計数法の薬学への応用　第１報　尿中の極低レベル｀１４´Ｃの測定
低バックグラウンド液体シンチレーション計数法の薬学への応用(第1報)尿中の極低レベル14Cの測定
テイバックグラウンドエキタイシンチレーションケイスウホウノヤクガクエノオウヨウダイ1ポウニョウチュウノゴクテイレベル 14C ノソクテイ

Search this article

Description

Utilization of a low background liquid scintillation counter(Low BG LSC)has been proposed for quantification of ultra-low level ¹⁴C in urine. The detector of this system is composed of a central counter and a guard counter, both of which are connected electronically with an anti-coincidence circuit. By this device the background(BG) counts can be decreased approximately to one third in comparison with a conventional liquid scintillation counter(LSC). Three photomultiplier tubes are used in Low BG LSC. High counting efficiency is also achieved by this improvement. 5mL of urine spiked with ¹⁴C is counted for 100 minutes and analyzed with the optimal window of multichannel analyzer. The limit of quantification(LOQ) that is defined as radioactivity giving10times standard deviation of BG sample is estimated to be 8.5 mBq per mL urine which is two times improved in comparison with accelerator mass spectrometry. The linearities of sub-becquerel ¹⁴C counted for 10 and 100 minutes by use of Low BG LSC are compared with those of LSC. The figure of merit is four times improved in Low BG LSC.

Journal

RADIOISOTOPES

RADIOISOTOPES 58 (5), 169-178, 2009

Japan Radioisotope Association

Keywords

Details 詳細情報について

Export

Report a problem