Development of Analytical Method for <sup>14</sup>C Determination in Biomedical Sample by Laser Spectroscopy

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  • 高感度レーザー分光に基づく生体試料中放射性炭素同位体分析システムの開発
  • コウカンド レーザー ブンコウ ニ モトズク セイタイ シリョウ チュウ ホウシャセイ タンソ ドウイタイ ブンセキ システム ノ カイハツ
  • Development of analytical method for 14C determination in biomedical sample by laser spectroscopy

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Abstract

<p>In recent years, new method called “microdose study” has been developed to directly investigate pharmacokinetics in the human body using a limited amount of 14C labeled candidate compounds which is less than 100 µg or 1％ of the dose that yields pharmacological effects. Drug development costs are expected to be dramatically decreased by this new method. Since the required abundance sensitivity of 14C analysis in the microdose studies is 10−10–10−12, Accelerator Mass Spectrometry (AMS) is presently used for this purpose. However, the high cost and limited throughput in 14C analysis by AMS may prevent from wide expansion of the microdose studies to drug development. As an alternative method, we are developing 14C detection system based on Cavity Ring-Down Spectroscopy (CRDS) for microdose studies.</p>

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 67 (3), 85-91, 2018

    Japan Radioisotope Association

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