Antiallergic Agents from Natural Sources. 3. Structures and Inhibitory Effects on Nitric Oxide Production and Histamine Release of Five Novel Polyacetylene Glucosides from Bidens parviflora WILLD.
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- WANG Naili
- Department of Natural Products Chemistry, Shenyang Pharmaceutical University
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- YAO Xinsheng
- Department of Natural Products Chemistry, Shenyang Pharmaceutical University
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- ISHII Rie
- Saitama Institute of Public Health
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- KITANAKA Susumu
- College of Pharmacy, Nihon University
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説明
Five new polyacetylene glucosides, bidensyneosides A1, A2, B, C (1-4), and 3-deoxybidensyneoside B (5), have been isolated from the air-dried whole plant of Bidens parviflora WILLD. The structures were identified based on spectroscopic analysis, physicochemical properties, and application of the modified Mosher method to be 3(R), 8(E)-8-decene-4, 6-diyne-1, 3-diol 1-O-β-D-glucopyranoside (1), deca-3(R), 8(Z) 8-decene-4, 6-diyne-1, 3-diol 1-O-β-D-glucopyranoside (2), 3(R)-deca-4, 6, 8-triyne-1, 3-diol 1-O-β-D-glucopyranoside (3), 3(R), 8(E)-8-decene-4, 6-diyne-1, 3, 10-triol 1-O-β-D-glucopyranoside (4), and 8(E)-8-decene-4, 6-diyne-1, 10-diol 1-O-β-D-glucopyranoside (5), respectively. These compounds inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-γ activated murine macrophages (RAW264.7) and also inhibited histamine release from rat mast cells stimulated by the antigen-antibody reaction.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 49 (8), 938-942, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204158392704
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- NII論文ID
- 110003616024
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXlvVCnu7w%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 5850720
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- PubMed
- 11515581
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可