Anti-androgenic Triterpenoids from the Brazilian Medicinal Plant, Cordia multispicata.
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- KUROYANAGI Masanori
- School of Bioresources, Hiroshima Prefectural University
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- SEKI Takahiro
- School of Pharmaceutical Sciences, University of Shizuoka
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- HAYASHI Tatsuo
- Life Science Center, Lion Corporation
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- NAGASHIMA Yoshio
- Life Science Center, Lion Corporation
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- KAWAHARA Nobuo
- Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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- SEKITA Setsuko
- Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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- SATAKE Motoyoshi
- Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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Compounds 1-6 were isolated from the AcOEt soluble fraction of leaves of the Brazilian medicinal plant, Cordia multispicata, and their structures were elucidated to be 3β, 25-epoxy-21β-acetoxy-3α, 22β-dihydroxyurs-12-en-28-al (1), 3β, 25-epoxy-28-acetoxy-3α, 21β, 22β-trihydroxyurs-12-ene (2), 21β-acetoxy-22β-hydroxy-3-oxours-12-en-28-al (3), 28-acetoxy-6β, 21β, 22β-trihydroxy-3-oxours-12-ene (4), 21β, 22β-dihydroxy-3-oxours-12-en-28-al (5) and 3β, 21β, 22β-trihydroxyurs-12-en-28-al (6), respectively, by means of spectral data, especially two dimensional NMR techniques. Triterpenes having the hemiketal structure at the A-ring, an acyloxy group at C-22 and/or ketone at C-3 showed potent anti-androgenic activity.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 49 (8), 954-957, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204158400640
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- NII論文ID
- 110003616027
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXlvVCnu7s%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 5850747
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- PubMed
- 11515584
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可