Novel Enantioselective Fluorinating Agents, (R)- and (S)-N-Fluoro-3-tert-butyl-7-nitro-3,4-dihydro-2H-benzo[e][1,2]thiazine l,1-Dioxides
書誌事項
- タイトル別名
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- Novel Enantioselective Fluorinating Agents, (R)- and (S)-N-Fluoro-3-tertbutyl-7-nitro-3,4-dihydro-2H-benzo [e] [1,2] thiazine 1,1-Dioxides.
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Enantioselective fluorinating agents, (R)- and (S)-N-fluoro-3-tert-butyl-7-nitro-3, 4-dihydro-2H-benzo[e][1, 2]-thiazine 1, 1-dioxides (BNBT-F, 2) are readily prepared in 3 steps from racemic 3-tert-butyl-7-nitro-3, 4-dihydro-2H-benzo[e][1, 2]thiazine 1, 1-dioxides (5) via optical resolution and fluorination. These agents make accessible both enantiomers of optically active quaternary α-fluoro carbonyl compounds in modest to high enantioselectivities. X-ray crystallographic analysis of chiral 2 reveals a unique structure wherein the nitrogen atom is highly pyramidalized and fluorine occupies an axial position.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 48 (12), 1954-1958, 2000
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204160800896
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- NII論文ID
- 110003635407
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 5584785
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- PubMed
- 11145150
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可