Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2′-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid
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- MANSURI-TORSHIZI Hassan
- Department of Chemistry, Faculty of Science, University of Sistan & Baluchestan
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- GHADIMY Saeid
- Department of Chemistry, Faculty of Science, University of Sistan & Baluchestan
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- AKBARZADEH Niloofar
- Department of Chemistry, Faculty of Science, University of Sistan & Baluchestan
書誌事項
- タイトル別名
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- Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2'-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid.
- Synthesis Characterization DNA Binding and Cytotoxic Studies of Platinum 2 and Palladium 2 Complexes of the 2 2 Bipyridine and an Anion of 1 1 Cyclobutanedicarboxylic Acid
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Two neutral complexes of formula [M(bpy)(cbdca)] [where M is palladium(II) (Pd(II)) or platinum(II) (Pt(II)), bpy is 2,2'-bipyridine and cbdca is anion of 1,1-cyclobutanedicarboxylic acid] have been synthesized. These water soluble complexes have been characterized by chemical analysis and conductivity measurements as well as 1H-NMR, ultraviolet-visible and infrared spectroscopy. In these complexes the ligand cbdca coordinates to Pt(II) or Pd(II) as bidentate with two oxygen atoms. They are nonelectrolyte in conductivity water. These complexes inhibit the growth of P388 lymphocytic leukemia cells and their targets are DNA. They invariably show ID50 values less than cisplatin. [Pt(bpy)(cbdca)] and [Pd(bpy)(cbdca)] have been interacted with calf thymus DNA and bind to DNA through coordinate covalent bond. In addition, the influence of binding of these complexes on the intensity of EtBr-DNA have been studied. They bind to DNA via a nonintercalating mode.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 49 (12), 1517-1520, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204161649664
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- NII論文ID
- 110003615829
- 30023110308
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXosl2rsLw%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 5995170
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- PubMed
- 11767068
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可