Optimum Conditions for the 13C-Phenylalanine Breath Test.
Bibliographic Information
- Other Title
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- Optimum Conditions for the 13C-Phenylal
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Abstract
We have conducted optimizaiton studies to develop a superior 13C-phenylalanine breath test for the diagnosis of liver disease. First, we examined the optimum 13C-labeling position in phenylalanine for use in a breath test based on infrared spectroscopic detection of 13CO2 in exhaled air. L-[1-13C]Phenylalanine gave the best result. Next, a suitable dosage to give a short peak time (the time expressed in minutes as which 13CO2 excretion is maximal) after administration was determined. The 13CO2/12CO2 ratio in exhaled air after administration of 100 mg/body of L-[1-13C]phenylalanine peaked sharply at 15 min. We also examined the effect of food on the hepatic metabolism of L-[1-13C]phenylalanine. We found that a fasting period of over 7 h before the test resulted in a higher 13CO2 peak excretion. The peak appeared sooner than that in the 13C-phenacetin breath test and, therefore, the 13C-phenylalanine breath test appears preferable for the rapid evaluation of hepatic function.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 46 (8), 1330-1332, 1998
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204161811328
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- NII Article ID
- 110003617031
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DyaK1cXlsFyju7o%3D
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- ISSN
- 13475223
- 00092363
- http://id.crossref.org/issn/00092363
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- NDL BIB ID
- 4540763
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- PubMed
- 9734317
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed