Synthesis and Physiological Activity of Novel Tocopheryl Glycosides.
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- SATOH Toshio
- Department of Bio-organic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- MIYATAKA Hideki
- Department of Bio-organic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- YAMAMOTO Kyozo
- Department of Bio-organic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- HIRANO Takashi
- Department of Bio-organic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Abstract
Vitamin E glycosides were synthesized and enzymatic hydrolysis was examined for use as potential prodrugs, however, the glycoside bond was found to be stable. On the other hand, among the glycosides synthesized, dl-α-tocopherylglucoside (6b) and dl-α-tocopherylmannoside (6c) showed strong inhibitory action on histamine release from mast cells. In addition, 6c also showed a suppressive action on IgE antibody formation. Thus, tocopheryl glycoside showed new properties compared to tocopherol (vitamin E). In particular, 6c was shown to be a novel lead compound with excellent manifold anti-allergic activity and anti-inflammatory activity.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 49 (8), 948-953, 2001
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204162067072
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- NII Article ID
- 110003616026
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXlvVCnu7o%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 5850738
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- PubMed
- 11515583
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed