The Influence of Microcrystalline Cellulose Grade on Shape and Shape Distributions of Pellets Produce Extrusion-Spheronization
-
- KOO Otilia May Yue
- Department of Pharmacy, National University of Singapore
-
- HENG Paul Wan Sia
- Department of Pharmacy, National University of Singapore
書誌事項
- タイトル別名
-
- The Influence of Microcrystalline Cellulose Grade on Shape and Shape Distributions of Pellets Produced by Extrusion-Spheronization.
- Influence of Microcrystalline Cellulose Grade on Shape and Shape Distributions of Pellets Produce Extrusion Spheronization
この論文をさがす
説明
In this study, five microcrystalline cellulose (MCC) grades were physically characterized and their extrusion-spheronization behaviours were characterized in terms of water requirements and pellet shape profiles. It was found that the MCC grades differed significantly in the physical properties investigated. Physical properties of MCC were found to influence the water requirement for extrusion-spheronization. MCC grades of higher bulk densities, lower porosities and water retentive capacities required less water to produce pellets of equivalent size. These MCC grades were also found to produce pellets of lower sphericity and wider shape distributions. Packing of MCC particles within the agglomerate played a role in determining amount of water retention and pellet rounding during spheronization. However, there was a limit to the influence of packing density on the rate of pellet rounding because poor packing resulted in higher water retentive capacity, which also limited the rate of rounding.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 49 (11), 1383-1387, 2001
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204162620160
-
- NII論文ID
- 110003615801
-
- NII書誌ID
- AA00602100
-
- COI
- 1:CAS:528:DC%2BD3MXotFagsbo%3D
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 5954059
-
- PubMed
- 11724226
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可