New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect.
書誌事項
- 公開日
- 1985
- 資源種別
- journal article
- DOI
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- 10.1248/cpb.33.3787
- 10.1002/chin.198613214
- 公開者
- 公益社団法人 日本薬学会
この論文をさがす
説明
In a search for new 1, 4-dihydropyridine derivatives with a long-lasting effect on the cardiovascular system, a series of piperazinylalkyl esters (I) bearing a lipophilic substituent on the 4-nitrogen of the piperazine ring was synthesized and tested for hypotensive effect in spontaneously hypertensive rats (SHR). Compounds I, especially those having a diphenylmethyl moiety on the piperazine ring, showed extremely potent and long-lasting hypotensive properties. Analogues related to I were also prepared, and the structure-activity relationships are discussed.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 33 (9), 3787-3797, 1985
公益社団法人 日本薬学会