Formulation Design of Ointment Base Suitable for Healing of Lesions in Treatment of Bedsores.
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- SHIGEYAMA Masato
- Department of Pharmacy, Takayama Red Cross Hospital
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- OHGAYA Toyoaki
- Department of Pharmacy, Takayama Red Cross Hospital
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- TAKEUCHI Hirofumi
- Department of Pharmaceutical Engineering Gifu Pharmaceutical University
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- HINO Tomoaki
- Department of Pharmaceutical Engineering Gifu Pharmaceutical University
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- KAWASHIMA Yoshiaki
- Department of Pharmaceutical Engineering Gifu Pharmaceutical University
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We intended to develop a desired ointment base suitable for treatment of bedsores including the proliferation of granulation and epidermis. The main bedsore bacteria detected in our hospital were S. aureus in gram-positive coccus and P. aeruginosa in gram-negative bacillus. As the macrogol ointment (MO) was found to have bactericidal effects on these bacteria, MO was adopted as the base for the objective ointment. To improve the properties of the ointment base such as regulating the humidity of the exudation and controlling the release of antibiotics formulated in the ointment, co-formulating effects of various additives to MO were evaluated. The sustained release function of the ointment base was obtained by adding hydrophilic petrolatum (HP) to MO. However, the resultant ointment was found to have a poor humidity regulating property. On the other hand, MO containing 5% of hydroxypropyl cellulose (HPC) showed both the humidity regulating and the controlled drug releasing properties. It was considered that HPC particles dispersed in the ointment could be swelled by absorbing water to form a gel network. The curd tension meter tests for the ointments prepared with the various polymers showed that the MO-HPC base, which showed the highest sustained drug releasing property, was found to have the highest hardness. This result means that HPC formulated into the base forms the most rigid gel structure to resist the erosion of the ointment and to control the drug release.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 49 (2), 129-133, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204163310464
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- NII論文ID
- 110003615859
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXhtVSitrg%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 5711789
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- PubMed
- 11217096
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可