Bioactive Constituents from Chinese Natural Medicines(11)Inhibitors on NO Production and Degranulation in RBL-2H3 from Rubia yunnanensis: Structures of Rubianosides 2, 3, and 4, Rubianol-g, and Rubianthraquinone
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- Tao Jing
- Kyoto Pharmaceutical University
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- Morikawa Toshio
- Kyoto Pharmaceutical University
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- Ando Shin
- Kyoto Pharmaceutical University
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- Matsuda Hisashi
- Kyoto Pharmaceutical University
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- Yoshikawa Masayuki
- Kyoto Pharmaceutical University
書誌事項
- タイトル別名
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- Bioactive Constituents from Chinese Natural Medicines. XI. Inhibitors on NO Production and Degranulation in RBL-2H3 from Rubia yunnanensis: Structures of Rubianosides II, III, and IV, Rubianol-g, and Rubianthraquinone
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抄録
Three new arborinane-type triterpene glycosides, rubianosides II, III, and IV, a new arborinane-type triterpene, rubianol-g, and a new anthraquinone, rubianthraquinone, were isolated from a Chinese natural medicine, the roots of Rubia yunnanensis. The structures of the new constituents including their absolute configurations were determined on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated constituents on nitric oxide production in lipopolysaccharide-activated macrophages were examined. Among them, a cyclic peptide constituent, RA-XII and its aglycon, RA-V (deoxybouvadin), potently inhibited overproduction of nitric oxide and induction of inducible nitric oxide synthase. In addition, an anthraquinone constituent, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, was found to show inhibitory effects on the release of β-hexosaminidase in RBL-2H3 cells.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 51 (6), 654-662, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204163417088
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- NII論文ID
- 110003615371
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3sXls1Kntrk%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 6541559
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- PubMed
- 12808242
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可