1-Oxo-2-hydroxy-l,2-dihydroacronycine: A Useful Synthon in the Acronycine Series for the Introduction of Amino Substituents at 6-Position and for the Conversion into Isopropylfuroacridones
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- MAGIATIS Prokopios
- Laboratory of Pharmacognosy, University of Athens
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- MITAKU Sofia
- Laboratory of Pharmacognosy, University of Athens
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- SKALTSOUNIS Alexios-Leandros
- Laboratory of Pharmacognosy, University of Athens
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- TILLEQUIN François
- Laboratoire de Pharmacognosie de l’Université René Descartes, UMR/CNRS N<SUP>0</SUP> 8638, Faculté des Sciences Pharmaceutiques et Biologiques
書誌事項
- タイトル別名
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- 1-Oxo-2-hydroxy-1,2-dihydroacronycine: A Useful Synthon in the Acronycine Series for the Introduction of Amino Substituents at 6-Position and for the Conversion into Isoproplfuroacridones.
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説明
Thermic aromatic nucleophilic displacement of the methoxy group at C-6 of (±)-1-oxo-2-hydroxy-1,2-dihydroacronycine (2) by an amine is a reaction that gives a facile entry to acronycine derivatives bearing an amino substituent at this position. The introduction of the amino substituents was confirmed with a long-range 1H-15N correlation NMR spectrum at natural abundance. Under basic conditions, compound 2 can also be rearranged to the corresponding isopropylfuroacridone 12, in 80% yield.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 49 (10), 1304-1307, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204164026368
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- NII論文ID
- 110003615780
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD3MXnt1Cktrs%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 5926661
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- PubMed
- 11605659
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 使用不可