N-to-C Solid-Phase Peptide and Peptide Trifluoromethylketone Synthesis Using Amino Acid tert-Butyl Esters.

DOI Web Site Web Site PubMed 被引用文献1件 参考文献37件
  • Gutheil William G.
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City
  • Xu Qingchai
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City

この論文をさがす

抄録

Solid-phase peptide synthesis in the N-to-C direction, opposite to the classical C-to-N direction of peptide synthesis, provides the synthetically versatile C-terminal carboxyl group for further modification into C-terminally modified peptide mimetics. These are of general interest as potential bioactive agents, particularly as protease inhibitors. Elaboration of peptide mimetics on the solid-phase would facilitate synthesis of peptide mimetic combinatorial libraries. This report describes an effective strategy for solid-phase inverse peptide synthesis based on readily available amino acid tert-butyl esters. The potential of this approach for peptide mimetic synthesis is demonstrated by the solid-phase synthesis of two peptide trifluoromethylketones.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (37)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ