Bioactive Saponins and Glycosides. XIV. Structure Elucidation and Immunological Adjuvant Activity of Novel Protojujubogenin Type Triterpene Bisdesmosides, Protojujubosides A, B, and B1, from the Seeds of Zizyphus jujuba var. spinosa (Zizyphi Spinosi Semen).

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Abstract

Following the elucidation of jujubosides A1 and C and acetyljujuboside B, novel protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B1, were isolated from Zizyphi Spinosi Semen, the seeds of Zizyphus jujuba MILL. var. spinosa HU. The structures of protojujubosides A, B, and B1 were determined on the basis of chemical and physicochemical evidence, which included the conversion of protojujubosides to known jujubosides using enzymatic hydrolysis. Protojujubosides A and jujubosides A, B, and C were found to show potent immunological adjuvant activity.

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