Synthetic Models Related to Furanocoumarin-CYP 3A4 Interactions. Comparison of Furanocoumarin, Coumarin, and Benzofuran Dimers as Potent Inhibitors of CYP3A4 Activity

DOI Web Site Web Site 被引用文献1件 参考文献21件
  • Oda Kazuaki
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Yamaguchi Yuki
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Yoshimura Teruki
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Wada Keiji
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Nishizono Naozumi
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

この論文をさがす

説明

Furanocoumarin derivatives (dimers and monomers) present in commercially available grapefruit juice have the capacity to inhibit the activity of human CYP3A4. Such interactions are believed to result from the mechanism-based inhibition of CYP3A4 activity in the intestine. The aim of this work was to synthesize and test a series of dimers with a view to determining the relationship between structure and inhibitory activity and determining whether they might make suitable probes of CYP3A4 activity. We prepared a series of furanocoumarin, coumarin, and benzofuran derivatives that have inhibitory effects on the activity of human CYP3A4. A synthetic benzofuran dimer, which is more accessible than furanocoumarin dimers, exhibited activity against CYP3A4 comparable to that of furanocoumarin dimers.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (21)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ