Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4]Triazolo[1,5-c]quinazolines

DOI Web Site Web Site 参考文献31件
  • Balo Carmen
    Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela
  • López Carmen
    Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela
  • Brea José Manuel
    Departamento de Farmacología, Facultade de Farmacia, Universidade de Santiago de Compostela
  • Fernánde Franco
    Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela
  • Caamaño Olga
    Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela

書誌事項

公開日
2007
DOI
  • 10.1248/cpb.55.372
公開者
公益社団法人 日本薬学会

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説明

A series of [1,2,4]triazolo[1,5-c]quinazolines were prepared in satisfactory yields by reaction of some derivatives of 2-aminobenzohydrazide with several hydrochlorides of aromatic amidines, and their binding affinities for the recombinant human adenosine A2A and A2B receptors were determined. None of the new compounds showed noteworthy affinity for these receptors, though a very high affinity for the A2A receptor and, consequently, a high level of A2A/A2B selectivity was revealed for one of the synthesized compounds.

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