Neurite Outgrowth-Promoting Active Constituents of the Japanese Cypress (Chamaecyparis obtusa)
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- Kuroyanagi Masanori
- Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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- Ikeda Ryuya
- Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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- Gao Hui Yuan
- School of Traditional Chinese Medicines, Shenyang Pharaceutical University
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- Muto Norio
- Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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- Otaki Keisuke
- Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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- Sano Toshikazu
- Hiroshima Prefectural Forestry Research Center
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- Kawahara Nobuo
- National Institute of Health Sciences
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- Nakane Takahisa
- Showa Pharmaceutical University
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Abstract
In the screening of biologically active constituents from woody plants, the methanol extract of leaves of Chamaecyparis obtusa showed potent neurite outgrowth-promoting activity in neuronal PC12 cells. The ethyl acetate-soluble fraction of the methanol extract showed potent activity and was separated by means of various chromatographic methods to give the two new compounds 1 and 2, as well as 11 known lignan and sesquiterpene derivatives. The structures of the new compounds were determined to be 9-O-acetyldihydrosesamin (1) and 9-O-(11-hydroxyeudesman-4-yl)dihydrosesamin (2), respectively, in NMR studies including 2D-NMR experiments. Of the 13 compounds, the known compound hinokinin (5) and the new compound 2 showed potent neurite outgrowth-promoting activity in PC 12 cells.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 56 (1), 60-63, 2008
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204168569088
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- NII Article ID
- 110006531691
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 9313267
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed