Effects of Magnesium Salts and Amines on the Stereoselectivity in the Imine Aldol Reaction
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- Hayashi Kazuhiko
- College of Pharmacy, Kinjo Gakuin University
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- Kujime Eiko
- College of Pharmacy, Kinjo Gakuin University
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- Katayama Hajime
- College of Pharmacy, Kinjo Gakuin University
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- Sano Shigeki
- Graduate School of Pharmaceutical Sciences, The University of Tokushima
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- Nagao Yoshimitsu
- Graduate School of Pharmaceutical Sciences, The University of Tokushima
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Abstract
In the imine aldol reactions of 1 with aromatic aldehydes using magnesium salts in the presence of amines, the threo/erythro ratios of products increased in the order Mg(ClO4)2>MgI2>MgBr2>MgCl2>Mg(OTf)2 and N,N,N′,N′-tetramethylethylenediamine (TMEDA)>Et3N. This increase in the threo/erythro ratios of products was estimated to be caused by a retro-imine aldol reaction under thermodynamic control.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 55 (12), 1773-1775, 2007
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204168630016
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- NII Article ID
- 110006532126
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 9274205
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
