Marine Diterpenoids with a Briarane Skeleton from the Okinawan Soft Coral Pachyclavularia violacea

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  • Ito Hisanaka
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
  • Iwasaki Junya
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
  • Sato Yuki
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
  • Aoyagi Miwako
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
  • Iguchi Kazuo
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
  • Yamori Takao
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research

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抄録

Five new briarane-type diterpenoids, pachyclavulides E (5), F (6), G (7), H (8) and I (9), were isolated from the Okinawan soft coral Pachyclavularia violacea. The structures of these compounds were elucidated based on the results of spectroscopic analysis. Compound 5 showed a weak growth-inhibitory activity in vitro toward cancer cells.

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