Leishmanicidal Active Constituents from Nepalese Medicinal Plant Tulsi (Ocimum sanctum L.)

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  • Suzuki Akiko
    Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
  • Shirota Osamu
    Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
  • Mori Kanami
    Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
  • Sekita Setsuko
    Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
  • Fuchino Hiroyuki
    Research Center of Medicinal Plant Resources, National Institute of Biomedical Innovation
  • Takano Akihito
    Showa Pharmaceutical University
  • Kuroyanagi Masanori
    Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima

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  • ChemInform Abstract: Leishmanicidal Active Constituents from Nepalese Medicinal Plant Tulsi (Ocimum sanctum L.).

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In the course of screening leishmanicidal active compounds from Asian and South American medicinal plants, a Nepalese medicinal plant, Tulsi (Ocimum sanctum L.), showed strong activity. We therefore studied the isolation and structural elucidation of the active constituents from O. sanctum L. From the ethyl acetate soluble fraction of the plant, seven new novel neolignan derivatives were isolated along with 16 known compounds. The structures of the new compounds (1—7) were elucidated as 6-allyl-3′,8-dimethoxy-flavan-3,4′-diol (1), 6-allyl-3-(4-allyl-2-methoxyphenoxy)-3′,8-dimethoxyflavan-4′-ol (2), 5-allyl-3-(4-allyl-2-methoxyphenoxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-2,3-dihydrobenzofuran (3), 1,2-bis(4-allyl-2-methoxyphenoxy)-3-(4-hydroxy-3-methoxyphenyl)-3-methoxypropane (4), 1-(4-hydroxy-3-methoxyphenyl)-1,2,3-tris(4-allyl-2-methoxyphenoxy)propane (5), 1-allyl-4-(5-allyl-2-hydroxy-3-methoxyphenoxy)-3-(4-allyl-2-methoxyphenoxy)-5-methoxybenzene (6), and 3-(5-allyl-2-hydroxy-3-methoxyphenyl)-1-(4-hydroxy-3-methoxyphenoxy)-prop-1-ene (7) by means of 1H-NMR, 13C-NMR, and 2D-NMR spectral data. Some of these compounds showed leishmanicidal activity.

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