Synthesis and Evaluation of Urea and Thiourea Derivatives of Oxazolidinones as Antibacterial Agents
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- Aaramadaka Sunil Kumar Reddy
- New Drug Discovery, Orchid Chemicals & Pharmaceuticals Ltd.
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- Guha Mrinal kanthi
- New Drug Discovery, Orchid Chemicals & Pharmaceuticals Ltd.
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- Prabhu Ganesh
- New Drug Discovery, Orchid Chemicals & Pharmaceuticals Ltd.
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- Kini Suvarna Ganesh.
- Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences
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- Vijayan Magesh
- New Drug Discovery, Orchid Chemicals & Pharmaceuticals Ltd.
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説明
Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 55 (2), 236-240, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204169342720
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- NII論文ID
- 110006162431
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 8615960
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
