Effects of Compression on the Interaction between 1,4-Dihydropyridine Compounds and Lactose Monohydrate (II): Differences in Powder Properties of 1,4-Dihydropyridine Compounds
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- Hosaka Shouichi
- Research and Development Division, Sawai Pharmaceutical Co., Ltd.
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- Sadoshima Takeshi
- Research and Development Division, Sawai Pharmaceutical Co., Ltd.
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- Sato Mika
- Research and Development Division, Sawai Pharmaceutical Co., Ltd.
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- Hamada Chikayuki
- Research and Development Division, Sawai Pharmaceutical Co., Ltd.
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- Takahashi Yoshiteru
- Research and Development Division, Sawai Pharmaceutical Co., Ltd.
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- Kitamori Nobuyuki
- Research and Development Division, Sawai Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- Effects of compression on the interaction between 1,4-dihydropyridine compounds and lactose monohydrate (2) Differences in powder properties of 1,4-dihydropyridine compounds
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Abstract
The solid-state interaction between manidipine dihydrochloride (Man) or benidipine hydrochloride (Ben) and lactose monohydrate (Lac) was investigated. An endothermic peak area at 170 °C was observed when their mixtures were subjected to differential scanning calorimetry (DSC) measurement, and this interaction was accelerated by compression. In the present study, dependency on the particle size of Lac was examined in this solid-state interaction. The DSC peak area at 170 °C as a function of the compression force profile was influenced by different particle sizes of Lac in combination with the two medicinal compounds in a different manner. The profile of the onset temperature of Lac dehydration, which indicates the degree of crystalline structure disruption, changed with differing Lac particle size. Moreover, when the particle size of Lac was large, the dehydration onset temperature of Lac with Man decreased from the lower compression force than that of Lac with Ben. The reason for this is thought to be the difference in the powder properties between Man and Ben, although the physicochemical properties of Man and Ben are similar.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 55 (5), 793-795, 2007
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204169565312
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- NII Article ID
- 110006273068
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 8714420
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed