Oxidation of 3-Hydroxypiperidines with Iodosylbenzene in Water: Tandem Oxidative Grob Fragmentation-Cyclization Reaction
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- Tada Norihiro
- Faculty of Pharmaceutical Sciences, University of Tokushima
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- Miyamoto Kazunori
- Faculty of Pharmaceutical Sciences, University of Tokushima
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- Ochiai Masahito
- Faculty of Pharmaceutical Sciences, University of Tokushima
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Description
Oxidation of 3-hydroxypiperidine with iodosylbenzene in water afforded 2-pyrrolidinone directly in good yields. The reaction probably involves oxidative Grob fragmentation yielding imino aldehyde, which upon hydrolysis produces 2-pyrrolidinone via a cyclization–oxidation sequence.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 52 (9), 1143-1144, 2004
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204169651712
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- NII Article ID
- 110003615738
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 15340208
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed