Further Cytotoxic Sesquiterpene Lactones from Elephantopus mollis KUNTH

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  • Tabopda Turibio Kuiate
    Département de Chimie Organique, Université de Yaoundé I Laboratoire de Chimie Organique des Substances Naturelles, UMR 7177 CNRS–Université Louis Pasteur
  • Ngoupayo Joseph
    Département de Chimie Organique, Université de Yaoundé I
  • Liu Jiawei
    Laboratoire de Chimie Organique des Substances Naturelles, UMR 7177 CNRS–Université Louis Pasteur
  • Shaiq Ali Muhammad
    H.E.J. Research Institute of Chemistry, University of Karachi
  • Khan Shamsun Nahar
    H.E.J. Research Institute of Chemistry, University of Karachi
  • Ngadjui Bonaventure Tchaleu
    Département de Chimie Organique, Université de Yaoundé I
  • Luu Bang
    Laboratoire de Chimie Organique des Substances Naturelles, UMR 7177 CNRS–Université Louis Pasteur

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説明

Three new sesquiterpene lactones, (4βH)-5α-hydroxy-8α-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6α-olide (1), (4βH)-8α-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6α-olide (2) and 2,5-epoxy-2β-hydroxy-4α-methoxy-8α-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6α-olide (3), have been isolated from roots and stems of Elephantopus mollis together with two known sesquiterpene lactones (4, 5). The identification of the isolates was accomplished by spectroscopic methods. Compounds (1—5) exhibited significant cytotoxic activities against mouse neuroblastoma B104 cells.

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