Bioactive Constituents from Chinese Natural Medicines. XX. Inhibitors of Antigen-Induced Degranulation in RBL-2H3 Cells from the Seeds of <i>Psoralea corylifolia</i>

Bibliographic Information

Other Title
  • Bioactive Constituents from Chinese Natural Medicines(20)Inhibitors of Antigen-Induced Degranulation in RBL-2H3 Cells from the Seeds of Psoralea corylifolia
  • Bioactive constituents from Chinese natural medicines. XX. Inhibition of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia

Search this article

Abstract

The ethyl acetate-soluble fraction of the methanolic extract from the seeds of Psoralea corylifolia was found to inhibit the release of β-hexosaminidase, as a marker of antigen-IgE-induced degranulation in RBL-2H3 cells. Sixteen constituents were isolated from the ethyl acetate-soluble fraction and several constituents, Δ1,3-hydroxybakuchiol (IC50=49 μM), Δ3,2-hydroxybakuchiol (69 μM, bavachin (58 μM), and psoralidin (ca. 100 μM), showed inhibitory activities against the antigen-induced degranulation.

Journal

Citations (13)*help

See more

References(76)*help

See more

Related Projects

See more

Details 詳細情報について

Report a problem

Back to top