Cytotoxic bisnor- and norditerpene dilactones having 7α,8α-epoxy-9,11-enolide substructure from Podocarpus macrophyllus D. DON

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  • Cytotoxic Bisnor- and Norditerpene Dilactones Having 7.ALPHA.,8.ALPHA.-Epoxy-9,11-enolide Substructure from Podocarpus macrophyllus D. DON
  • Cytotoxic bisnor and norditerpene dilactones having 7 a 8 a epoxy 9 11 enolide substructure from Podocarpus macrophyllus D DON

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Fourteen new bisnor- and norditerpene dilactones, makilactones E—R, having a 7α : 8α-epoxy-9,11-enolide substructure, were isolated from a methanolic extract of the root and the bark of Podocarpus macrophyllus D. DON (Podocarpaceae) with thirteen known bisnor- and norditerpenoids, and the structures of those new bisnor- and norditerpenoids were determined on the basis of their spectroscopic studies. Of the thirteen known ones isolated, the structures of two, i.e., podolactone B and inumakilactone B, were revised on the basis of X-ray crystallographic analysis and spectroscopic analysis. Many of the compounds of this type isolated in this study showed potent cytotoxic activities against P388 murine leukemia cells.

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