New Organoselenium Compounds Active against Pathogenic Bacteria, Fungi and Viruses
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- Piętka-Ottlik Magdalena
- Department of Organic Chemistry, Faculty of Chemistry, Wrocław University of Technology
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- Wójtowicz-Młochowska Halina
- Department of Organic Chemistry, Faculty of Chemistry, Wrocław University of Technology
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- Kołodziejczyk Katarzyna
- Department of Organic Chemistry, Faculty of Chemistry, Wrocław University of Technology
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- Piasecki Egbert
- Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
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- Młochowski Jacek
- Department of Organic Chemistry, Faculty of Chemistry, Wrocław University of Technology
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Different N-substituted benzisoselenazol-3(2H)-ones, analogues of ebselen were designed as new antiviral and antimicrobial agents. We report their synthesis, chemical properties as well as study on biological activity against broad spectrum of pathogenic microorganisms (Staphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV)), in vitro. Most of them exhibited high activity against viruses (HSV-1, EMCV) and gram-positive bacteria strains (S. aureus, S. simulans), while their activity against gram-negative bacteria strains (E. coli, P. aeruginosa, K. pneumoniae) was substantially lower. Some of tested compounds were active against yeast C. albicans and filamentous fungus A. niger.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 56 (10), 1423-1427, 2008
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204170858240
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- NII論文ID
- 110006936292
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 9655062
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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