Synthesis of New 2-Naphthyl Ethers and Their Protective Activities against DNA Damage Induced by Bleomycin-Iron
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- Abdel-Wahab Bakr F.
- Applied Organic Chemistry Department, National Research Center
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- El-Ahl Abdel-Aziz S.
- Chemistry Department, Umm Al-Qura University, University College Makah
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- Badria Farid A.
- Pharmacognosy Department, Faculty of Pharmacy, Mansoura University
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The reaction of 2-naphthaloxyacetic acid with thiosemicarbazide in the presence of phosphoryl chloride, followed by treatment with phenacylbromides, led to the formation of imidazo[2,1-b][1,3,4]thiadiazoles 3a—c. 2-(Naphthalen-3-yloxy)acetohydrazide 4 on treatment with ethyl 2-(2-arylhydrazono)-3-oxobutanoates (5a—c), 2-methoxymethylene)malononitrile, or ethyl 2-cyano-3,3-bis(methylthio)acrylate led to the formation of substituted pyrazoles 6—8. The reaction of the hydrazide 4 with hydrazonoyl chlorides 9a—c and 1,2,4,5-benzene tetracarboxylic-1,2:4,5-dianhydride produced bis-diazo compounds 10a—c and dimide 11 respectively. All new compounds were tested for their protective activity against DNA damage induced by bleomycin–iron complex. Compound 2 showed the greatest protection against DNA damage, thus diminishing chromogen formation between the damaged DNA and thiobarbituric acid.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 57 (12), 1348-1351, 2009
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204170894080
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- NII論文ID
- 130000124533
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10455100
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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