Bioactive constituents from Chinese natural medicines (26) Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis
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- Nakamura Seikou
- Kyoto Pharmaceutical University
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- Li Xuezheng
- Kyoto Pharmaceutical University
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- Matsuda Hisashi
- Kyoto Pharmaceutical University
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- Ninomiya Kiyofumi
- Pharmaceutical Research and Technology Institute, Kinki University
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- Morikawa Toshio
- Pharmaceutical Research and Technology Institute, Kinki University
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- Yamaguti Kikuji
- Japan Royal Jelly Co., Ltd.
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- Yoshikawa Masayuki
- Kyoto Pharmaceutical University
書誌事項
- タイトル別名
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- Bioactive Constituents from Chinese Natural Medicines. XXVI. Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis
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抄録
The methanolic extract from the roots of Rhodiola sachalinensis was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, five new glycosides, two monoterpene glycosides, two flavonol bisdesmosides, and a cyanogenic glycoside, were isolated together with 34 known compounds. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, sachalosides III and IV, rhodiosin, and trans-caffeic acid, displayed hepatoprotective effects.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 55 (10), 1505-1511, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204170909440
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- NII論文ID
- 110006404700
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD2sXhtl2qs7fM
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 8919041
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- PubMed
- 17917296
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可