Clerodane Diterpenoids and Flavonoids with NGF-Potentiating Activity from the Aerial Parts of Baccharis gaudichaudiana

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  • Guo Yuanqiang
    Department of Pharmaceutical Sciences, Nankai University
  • Li Yushan
    Research Department of Natural Medicine, Shenyang Pharmaceutical University
  • Xu Jing
    Department of Pharmaceutical Sciences, Nankai University
  • Li Ning
    Research Department of Natural Medicine, Shenyang Pharmaceutical University
  • Yamakuni Tohru
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University
  • Ohizumi Yasushi
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University

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抄録

A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with three known clerodane diterpenes (2—4) and three known flavones (5—7), were isolated from the aerial parts of Baccharis gaudichaudiana. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

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