A Facile Synthesis of p- and m-(Amidinomethyl)phenyl Esters Derived from Amino Acid and Tryptic Hydrolysis of These Synthetic Inverse Substrates
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- Sekizaki Haruo
- Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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- Itoh Kunihiko
- Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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- Shibuya Akiyoshi
- Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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- Toyota Eiko
- Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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- Tanizawa Kazutaka
- Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Abstract
A facile synthetic method for p- and m-(amidinomethyl)phenyl esters derived from a variety of amino acids is presented. We analyzed the kinetic behavior of trypsin towards these synthetic esters, which are inverse substrates. The substituent (meta- and para-isomers) and isosteric effects of (amidinomethyl)phenyl esters are discussed.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 55 (10), 1514-1517, 2007
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204170933120
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- NII Article ID
- 110006404702
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 8919068
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed