Xeniaphyllane-Derived Terpenoids from the Formosan Soft Coral Sinularia gibberosa

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  • Chen Shin-Pin
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University
  • Su Jui-Hsin
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University
  • Ahmed Atallah Fouad
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University
  • Dai Chang-Feng
    Institute of Oceanography, National Taiwan University
  • Wu Yang-Chang
    Graduate Institute of Natural Products, Kaohsiung Medical University
  • Sheu Jyh-Horng
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University Asian Pacific Ocean Research Center, National Sun Yat-sen University

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New xeniaphyllane-derived metabolites (1—7) were isolated from the EtOAc extract of the Formosan soft coral Sinularia gibberosa. The structures and relative configurations of these compounds were elucidated on the basis of extensive spectroscopic analysis (including 2D NMR) and by comparison of their spectral data with those of related compounds. In vitro cytotoxic evaluation of the above metabolites towards a limited panel of cancer cell lines is also described.

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