Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed II. A Proposal of a Rapid Dissolution Test for Evaluation of Bitter Taste of Ibuprofen
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- Hamashita Tomohiro
- Oral Solid Formulation, R&D Laboratories, Self Medication Business, Taisho Pharmaceutical Co., Ltd.
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- Matsuzaki Miwako
- Oral Solid Formulation, R&D Laboratories, Self Medication Business, Taisho Pharmaceutical Co., Ltd.
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- Ono Tetsuo
- Oral Solid Formulation, R&D Laboratories, Self Medication Business, Taisho Pharmaceutical Co., Ltd.
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- Ono Masaki
- Oral Solid Formulation, R&D Laboratories, Self Medication Business, Taisho Pharmaceutical Co., Ltd.
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- Tsunenari Yoshinobu
- Oral Solid Formulation, R&D Laboratories, Self Medication Business, Taisho Pharmaceutical Co., Ltd.
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- Aketo Takao
- Oral Solid Formulation, R&D Laboratories, Self Medication Business, Taisho Pharmaceutical Co., Ltd.
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- Watano Satoru
- Department of Chemical Engineering, Osaka Prefecture University
Bibliographic Information
- Other Title
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- Granulation of core particles suitable for film coating by agitation fluidized bed (2) A proposal of a rapid dissolution test for evaluation of bitter taste of ibuprofen
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Description
To prepare powdered drugs that do not have a bitter taste, a film coating covering the surfaces of the core particles is required. The dissolution rate of ibuprofen from the coated particles changes according to the physical properties of the core particles. In this study, the effects of the physical properties of granules prepared by using several scales of agitation fluidized beds on the drug dissolution rate were investigated. The dissolution rate of ibuprofen decreased when the apparent density and shape factor of the granules increased. In contrast, the dissolution rate of the drug increased with the friablility of the granules increased. Thus, the structures of the granules appear to affect the dissolution rate of the drug to a large degree. A rapid dissolution test that can be used to investigate the early dissolution rate of ibuprofen in vitro was proposed to evaluate the taste-masking level of the coated particles. The bitter taste-masking level of the coated particles was successfully confirmed by using this novel test method.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 56 (7), 883-887, 2008
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204170967808
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- NII Article ID
- 110006791961
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 9544539
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- PubMed
- 18591795
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed