Separation of Stereoisomers of Some Terpene Derivatives by Capillary Gas Chromatography-Mass Spectrometry and High-Performance Liquid Chromatography Using β-Cyclodextrin Derivative Columns
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- Kasai Hiroko F.
- Faculty of Pharmaceutical Sciences, Hoshi University
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- Tsubuki Masayoshi
- Faculty of Pharmaceutical Sciences, Hoshi University
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- Matsumoto Yohichiro
- Faculty of Pharmaceutical Sciences, Hoshi University
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- Shirao Mika
- Department of Human Nutrition, Jissen Women's Junior College
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- Takahashi Kazunori
- Faculty of Pharmaceutical Sciences, Hoshi University
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- Honda Toshio
- Faculty of Pharmaceutical Sciences, Hoshi University
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- Ueda Haruhisa
- Faculty of Pharmaceutical Sciences, Hoshi University
書誌事項
- タイトル別名
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- Separation of Stereoisomers of Some Terpene Derivatives by Capillary Gas Chromatography-Mass Spectrometry and High-Performance Liquid Chromatography Using .BETA.-Cyclodextrin Derivative Columns
- Separation of Stereoisomers of Some Terpene Derivatives by Capillary Gas Chromatography Mass Spectrometry and High Performance Liquid Chromatography Using ベータ Cyclodextrin Derivative Columns
この論文をさがす
抄録
Gas chromatographic separations of the stereoisomers of menthol derivatives, important intermediates in the synthesis of physiologically active natural products, were carried out on several substituted β-cyclodextrin (CD) columns, including per-O-methyl-β-cyclodextrin (PME-β-CD), heptakis(2,3-di-O-acetyl-6-tert-butyldimethylsilyl)-β-CD (DIAC-6-TBDS-β-CD), and heptakis(2,3-di-O-methyl-6-tert-butyldimethylsilyl)-β-CD (DIME-6-TBDS-β-CD) as chiral stationary phases (CSPs). With the DIME-6-TBDS-β-CD column, a separation of the Z- and E-isomers of methylidenementhol was accomplished; no separation was achieved with the other columns. The stereoisomers of methylidenementhol and the corresponding tert-butyldimethylsilyl (TBS) ether were separated on both the β-CD and the heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TME-β-CD) columns by high-performance liquid chromatography (HPLC) with a mobile phase involving acetonitrile and H2O. For the separation of the Z- and E-isomers of methylidenementhol, the TME-β-CD column was superior. In contrast, the β-CD column was preferable in the case of the corresponding TBS ether.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 52 (3), 311-315, 2004
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204171324544
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- NII論文ID
- 110003615556
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 6866973
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- PubMed
- 14993753
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可