Grinding-Induced Equimolar Complex Formation between Thiourea and Ethenzamide
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- Moribe Kunikazu
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Tsuchiya Masami
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Tozuka Yuichi
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Yamaguchi Kentaro
- Chemical Analysis Center, Chiba University
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- Oguchi Toshio
- Department of Pharmacy, University Hospital, Faculty of Medicine, University of Yamanashi
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- Yamamoto Keiji
- Graduate School of Pharmaceutical Sciences, Chiba University
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We prepared and characterized a grinding-induced equimolar complex of thiourea with ethenzamide. When thiourea and ethenzamide were co-ground at a molar ratio of 3 : 1, new powder X-ray diffraction (PXRD) peaks were observed in addition to PXRD peaks of thiourea crystals. The optimum stoichiometry of the new structure was confirmed as 1 : 1 mol/mol. Effect of grinding time on the thiourea–ethenzamide equimolar complex formation was investigated by using PXRD, differential scanning calorimetry and Fourier transform infrared spectroscopy. The equimolar crystal structure was confirmed by X-ray diffraction measurements of the single crystal which was recrystallized from ethanol. It was found that the intermolecular hydrogen bond formations between thiourea and ethenzamide molecules contributed to the equimolar complex formation. The complex formation was not observed in the cases where benzamide, salicylamide or 3-ethoxybenzamide was co-ground with thiourea. 2-Alcoxyl benzamide structures should be required for the grinding-induced equimolar complex formation with thiourea.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 52 (5), 524-529, 2004
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204171365888
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- NII論文ID
- 110003615607
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD2cXksVylt7k%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 6931221
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- PubMed
- 15133201
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可