Antitumor activity and DNA-binding investigations of the Zn(2) and Cu(2) complexes with isoeuxanthone
-
- Wang Huifang
- College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University
-
- Shen Rui
- College of Pharmacy Nankai University
-
- Wu Jincai
- College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University
-
- Tang Ning
- College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University
書誌事項
- タイトル別名
-
- Antitumor Activity and DNA-Binding Investigations of the Zn(II) and Cu(II) Complexes with Isoeuxanthone
この論文をさがす
抄録
Two new complexes ZnL2 (1) and CuL2 (2) (here, HL=isoeuxanthone) have been synthesized and characterized by elemental analyses, molar conductance, infrared spectra (IR), 1H-NMR and UV–Vis measurements. The interactions of them with calf thymus DNA (ct DNA) have been investigated by absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy and viscosity measurements. Experimental results revealed an intercalative interaction with DNA for the complexes; furthermore the binding affinity of 2 is higher than that of 1 according to the calculated binding constant values. In addition, they were evaluated for their cytotoxic activities toward human esophageal cancer (ECA109) and human gastric cancer (SGC7901) cells by MTT assay. Both of them showed significant cytotoxic potency.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 57 (8), 814-818, 2009
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204171433216
-
- NII論文ID
- 130000124165
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 10290470
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可