L-.BETA.-(5-Hydroxy-2-pyridyl)-alanine and L-.BETA.-(3-hydroxyureido)-alanine from streptomyces.
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Abstract
In the course of the chemical screening study on the metabolites from actinomycetes, two unusual amino acids were isolated : L-β-(5-Hydroxy-2-pyridyl)-alanine (1) and L-β-(3-hydroxyureido)-alanine (9). The structures of 1 and 9 were elucidated from the physico-chemical properties of these amino acids and derivatives, and supported by synthesis. Antibacterial activities of 1 and its methylester (2) were antagonized by L-tyrosine, and those of 9 and its derivative (17) by L-glutamine.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 23 (11), 2669-2677, 1975
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204171451136
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- NII Article ID
- 110003621755
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DyaE28XksVKgtw%3D%3D
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- ISSN
- 13475223
- 00092363
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- PubMed
- 1218439
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed