Two New Triterpenoid Saponins Isolated from Polygala japonica

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  • Wang Honglan
    Department of Traditional Chinese Prescription, China Pharmaceutical University
  • Gao Jie
    Department of Traditional Chinese Prescription, China Pharmaceutical University
  • Zhu Danni
    Department of Traditional Chinese Prescription, China Pharmaceutical University
  • Yu Boyang
    Department of Traditional Chinese Prescription, China Pharmaceutical University

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説明

Bioassay guided investigation of whole parts of Polygala japonica afforded two new triterpenoid saponins, characterized as 3-O-β-D-glucopyranosyl medicagenic acid 28-O-{β-D-xylopyranosyl(1→4)-[β-D-apiofuranosyl(1→3)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl} ester (1), 3-O-β-D-glucopyranosyl 2-oxo-olean-12-en-23, 28-dioic acid 28-O-{β-D-xylopyranosyl(1→4)-[β-D-apiofuranosyl(1→3)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl} ester (2), together with four known triterpenoid saponins (3—6). Their structures were elucidated by spectroscopic and chemical methods. Saponins 3, 4 and 5 showed significant anti-inflammation effects on carrageenan-induced acute paw edema in mouse.

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