Search this article
Abstract
The N-alkylation of DL-trans-and DL-cis-2-aminocyclohexanols was effected with alkylating agents in the presence of potassium carbonate. When lower alkylating agents were used, the trans form gave N-dialkyl derivatives, while the cis form gave only N-monoalkyl derivatives. The use of higher alkylating agents led both forms to N-monoalkyl derivatives. The resistance of the cis form to dialkylation in the presence of the lower alkylating agents was presumably due to a hydrogen bond between the hydroxyl and the amino groups in the cis relationship. This assumption may be supported by an analogous phenomenon which was already found in the Schotten-Baumann benzoylation of diasteromeric 2, 2'-dihydroxydicyclohexylamine.2, 15)
Journal
-
- Chemical and Pharmaceutical Bulletin
-
Chemical and Pharmaceutical Bulletin 11 (2), 222-225, 1963
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204171747968
-
- NII Article ID
- 110003661353
-
- NII Book ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL BIB ID
- 9245153
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed