Synthesis, Biological Activity of Salidroside and Its Analogues
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- Guo Yibing
- Jiangsu Key Laboratory of Neuroregeneration, Nantong University Medical School, Nantong University
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- Zhao Yahong
- Jiangsu Key Laboratory of Neuroregeneration, Nantong University
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- Zheng Cheng
- Institue of Nautical Medicine, Nantong University
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- Meng Ying
- Jiangsu Key Laboratory of Neuroregeneration, Nantong University
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- Yang Yumin
- Jiangsu Key Laboratory of Neuroregeneration, Nantong University
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Description
Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs–Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 μmol/l and 60 μmol/l, respectively.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 58 (12), 1627-1629, 2010
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204172392064
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- NII Article ID
- 130000405692
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3M%2Fis1Wgsg%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 10894905
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- PubMed
- 21139267
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed