Synthesis and Antiviral Activities of Synthetic Glutarimide Derivatives

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  • Ji Xing-yue
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
  • Zhong Zhao-jin
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
  • Xue Si-tu
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
  • Meng Shuai
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
  • He Wei-ying
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
  • Gao Rong-mei
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
  • Li Yu-huan
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
  • Li Zhuo-rong
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College

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A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, Cox B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger antiviral activity.

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