Antibacterial Activity of 5-Dialkylaminomethylhydantoins and Related Compounds
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- Fujisaki Fumiko
- Faculty of Pharmaceutical Science, Fukuoka University
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- Shoji Kaori
- Faculty of Pharmaceutical Science, Fukuoka University
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- Shimodouzono Mari
- Faculty of Pharmaceutical Science, Fukuoka University
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- Kashige Nobuhiro
- Faculty of Pharmaceutical Science, Fukuoka University
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- Miake Fumio
- Faculty of Pharmaceutical Science, Fukuoka University
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- Sumoto Kunihiro
- Faculty of Pharmaceutical Science, Fukuoka University
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抄録
To find new antibacterial leads in the class of hydantoin derivatives, we carried out synthetic investigation and biological evaluation of the title hydantoin derivatives and related compounds. Among the hydantoin derivatives described in this article, compound 3o, in which a 2,6-dichlorophenyl ring was introduced at the N-3 position of the hydantoin nucleus, showed the highest levels of antibacterial activity against both Escherichia coli NBRC14237 (NIHJ) and Staphylococcus aureus ATCC6538P (gram-negative and gram-positive bacteria, respectively) strains.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 58 (8), 1123-1126, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204172683392
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- NII論文ID
- 130000299829
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3cjis1KntA%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10764351
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- PubMed
- 20686274
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可