Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones
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- Rizvi Syed Umar Farooq
- Institute of Chemistry, University of the Punjab
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- Siddiqui Hamid Latif
- Institute of Chemistry, University of the Punjab
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- Parvez Masood
- Department of Chemistry, The University of Calgary
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- Ahmad Matloob
- Institute of Chemistry, University of the Punjab
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- Siddiqui Waseeq Ahmad
- Department of Chemistry, Ibn-e-Sina Block, University of Sargodha
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- Yasinzai Muhammad Masoom
- Institute of Biochemistry, Balochistan University
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説明
Thirty eight heterocyclic chalcones were synthesized by condensing formylquinolines with diverse methyl arylketones. The target compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. The X-ray crystallographic study of (2E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one (1p) was also performed for the structure confirmation. The title compounds were screened for anti-microbial and antileishmanial activities. The compounds 1c—e, 1g, 1j—m, 1p, 1r—s, 2g, 2j—p, and 2r—s were found potentially active antileishmanial agents, while 1f—i, 1l, 1o—p, 2f—i, 2l, and 2o—p showed remarkable antibacterial activity. Only compounds 1g and 2g—h exhibited significant antifungal activity.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 58 (3), 301-306, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204172690816
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- NII論文ID
- 130000255904
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10581848
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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