Inhibitory Effects of Acylated Acyclic Sesquiterpene Oligoglycosides from the Pericarps of Sapindus rarak on Tumor Necrosis Factor-.ALPHA.-Induced Cytotoxicity

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  • Morikawa Toshio
    Pharmaceutical Research and Technology Institute, Kinki University
  • Xie Yuanyuan
    Pharmaceutical Research and Technology Institute, Kinki University School of Traditional Chinese Medicine, Shenyang Pharmaceutical University
  • Ninomiya Kiyofumi
    Pharmaceutical Research and Technology Institute, Kinki University
  • Okamoto Masaki
    Pharmaceutical Research and Technology Institute, Kinki University
  • Muraoka Osamu
    Pharmaceutical Research and Technology Institute, Kinki University
  • Yuan Dan
    School of Traditional Chinese Medicine, Shenyang Pharmaceutical University
  • Yoshikawa Masayuki
    Pharmaceutical Research and Technology Institute, Kinki University Kyoto Pharmaceutical University
  • Hayakawa Takao
    Pharmaceutical Research and Technology Institute, Kinki University

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  • Inhibitory effects of acylated acyclic sesquiterpene oligoglycosides from the pericarps of Sapindus rarak on tumor necrosis factor-α-induced cytotoxicity
  • Inhibitory effects of acylated acyclic sesquiterpene oligoglycosides from the pericarps of Sapindus rarak on tumor necrosis factor a induced cytotoxicity

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Abstract

Four new acylated acyclic sesquiterpene oligoglycosides (1—4) were isolated from the pericarps of Sapindus rarak DC. together with four known acyclic sesquiterpene oligoglycosides, mukuroziosides Ia (5), Ib (6), IIa (7), and IIb (8). Their structures were elucidated on the basis of chemical and physicochemical evidence. These newly isolated compounds (1—4) were found to show inhibitory effects on tumor necrosis factor-α-induced cytotoxicity in L929 cells at concentrations of 30—100 μM.

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