A New Commercially Viable Synthetic Route for Donepezil Hydrochloride: Anti-Alzheimer's Drug
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- Dubey Shailendra Kumar
- Chemical and Pharma Research Department, Jubilant Organosys Limited
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- Kharbanda Manita
- Chemical and Pharma Research Department, Jubilant Organosys Limited
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- Dubey Sushil Kumar
- Chemical and Pharma Research Department, Jubilant Organosys Limited
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- Mathela Chandra Shekhar
- Department of Chemistry, Kumaun University
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An economical new process has been developed for the synthesis of donepezil hydrochloride (1) an anti-Alzheimer's drug. The process involves Darzen reaction of pyridine-4-carboxaldehyde and 2-bromo-5,6-dimethoxy indanone affording epoxide 5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2′-oxiran]-1(3H)-one (4) as a key intermediate. The one-pot deoxygenation of 4 and hydrogenation of the aryl moiety in high yield improved the overall yield of the process.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 58 (9), 1157-1160, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204172917760
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- NII論文ID
- 130000324588
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10796419
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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