Four New Cembrane Diterpenes Isolated from an Okinawan Soft Coral Lobophytum crassum with Inhibitory Effects on Nitric Oxide Production
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- Wanzola Mpanzu
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Furuta Takaaki
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Kohno Yasuhisa
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Fukumitsu Shunichi
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Yasukochi Shuhei
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Watari Kosuke
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Tanaka Chiaki
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Higuchi Ryuichi
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Miyamoto Tomofumi
- Graduate School of Pharmaceutical Sciences, Kyushu University
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抄録
Four new cembrane diterpenes (1—4) and fifteen known cembranoids (5—19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of α-methylene-γ-lactone, exhibited the significant effect on NO production.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 58 (9), 1203-1209, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204172925696
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- NII論文ID
- 130000324595
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3cfhsVegsw%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10796453
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- PubMed
- 20823600
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可